OUR RESEARCH

Building human immune “atlases” across organs and the human lifespan, and defining regulatory populations (including tissue-enriched CD8 regulatory T cells) that may protect and repair tissues.

We aim to understand how human regulatory T cells (Tregs) control immune responses. We are particularly interested in CD8 Tregs, an understudied population that is rare in the blood but found in similar numbers to CD4 Tregs in human tissues.

Through studying blood, cerebrospinal fluid and tissue, we aim to understand the mechanisms that drive neuroinflammatory diseases such as multiple sclerosis, with a particular focus on how and why immune regulation fails. Our goal is to identify new targets for more effective treatments.

Through studying post-mortem human brain tissue, we aim to understand the role of inflammation in neurodegenerative disorders such as Parkinson’s disease and progressive supranuclear palsy.